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CD8(+) T-cell autoreactivity to an HLA-B27–restricted self-epitope correlates with ankylosing spondylitis

HLA-B27 is highly associated with ankylosing spondylitis (AS), but the mechanism is unknown. Among the HLA-B27 alleles, B*2709, which differs by one amino acid from the susceptible B*2705, is not associated with the disease. Here, we analyze the reactivity, in patients with AS and in healthy control...

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Bibliografski detalji
Glavni autori: Fiorillo, Maria T., Maragno, Monica, Butler, Richard, Dupuis, Maria L., Sorrentino, Rosa
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC314361/
https://ncbi.nlm.nih.gov/pubmed/10880047
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