CD8(+) T-cell autoreactivity to an HLA-B27–restricted self-epitope correlates with ankylosing spondylitis

HLA-B27 is highly associated with ankylosing spondylitis (AS), but the mechanism is unknown. Among the HLA-B27 alleles, B*2709, which differs by one amino acid from the susceptible B*2705, is not associated with the disease. Here, we analyze the reactivity, in patients with AS and in healthy control...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Fiorillo, Maria T., Maragno, Monica, Butler, Richard, Dupuis, Maria L., Sorrentino, Rosa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314361/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880047/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9295
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