Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation

Rodents given a supramaximally stimulating dose of cholecystokinin or its analogue cerulein develop acute pancreatitis with acinar cell injury, pancreatic inflammation, and intrapancreatic digestive enzyme (i.e., trypsinogen) activation. Prior thermal stress is associated with heat shock protein 70...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Bhagat, Lakshmi, Singh, Vijay P., Hietaranta, Antti J., Agrawal, Sudhir, Steer, Michael L., Saluja, Ashok K.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 2000
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC314357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10880051/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8706
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