Structure-Activity relationship in mutated pyrazinamidases from Mycobacterium tuberculosis

The pncA gene codes the pyrazinamidase of Mycobacterium tuberculosis, which converts pyrazinamide to ammonia and pyrazinoic-acid, the active antituberculous compound. Pyrazinamidase mutations are associated to pyrazinamide-resistant phenotype, however how mutations affect the structure of the pyrazi...

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Main Authors: Quiliano, Miguel, Gutierrez, Andres Hazaet, Gilman, Robert Hugh, López, César, Evangelista, Wilfredo, Sotelo, Jun, Sheen, Patricia, Zimic, Mirko
Format: Artigo
Sprog:Inglês
Udgivet: Biomedical Informatics 2011
Fag:
Hypothesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143395/
https://ncbi.nlm.nih.gov/pubmed/21814390
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