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Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

We used intravital microscopy to observe the formation of platelet plugs in ferric chloride–injured arterioles of live mice. With this model, we evaluated thrombus growth in mice lacking von Willebrand factor (vWF) and fibrinogen (Fg), the two key ligands known to mediate platelet adhesion and aggre...

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Autors principals: Ni, Heyu, Denis, Cécile V., Subbarao, Sangeetha, Degen, Jay L., Sato, Thomas N., Hynes, Richard O., Wagner, Denisa D.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC314330/
https://ncbi.nlm.nih.gov/pubmed/10930441
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