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EPR SPECTRA AND MOLECULAR DYNAMICS AGREE THAT THE NUCLEOTIDE POCKET OF MYOSIN V IS CLOSED AND THAT IT OPENS ON BINDING ACTIN
We have used EPR spectroscopy and computational modeling of nucleotide-analog spin probes to investigate conformational changes at the nucleotide site of myosin V (MV). We find that in the absence of actin, the mobility of a spin-labeled diphosphate analog (SLADP) bound at the active site is strongl...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3143297/ https://ncbi.nlm.nih.gov/pubmed/21640122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.05.019 |
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