Mutation in the FMN Domain Modulates MCD Spectra of the iNOS Ferric Cyano Complex in a Substrate-Specific Manner

We have obtained low temperature MCD spectra for ferric cyano complexes of the wild type and E546N mutant of a human iNOS oxygenase/FMN construct. The mutation at the FMN domain has previously been shown to modulate the MCD spectra of the L-arginine-bound ferric iNOS heme [Sempombe et al., J. Am. Ch...

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Hauptverfasser: Sempombe, Joseph, Galinato, Mary Grace I., Elmore, Bradley O., Fan, Weihong, Guillemette, J. Guy, Lehnert, Nicolai, Kirk, Martin L., Feng, Changjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143224/
https://ncbi.nlm.nih.gov/pubmed/21718007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ic200952c
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