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Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
Protein kinase PKR is activated during viral infection and phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF2), leading to inhibition of translation and viral replication. We report fast evolution of the PKR kinase domain in vertebrates, coupled with positive selection...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3142916/ https://ncbi.nlm.nih.gov/pubmed/19043413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1529 |
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