Intracellular free zinc up-regulates IFN-γ and T-bet essential for Th(1) differentiation in Con-A stimulated HUT-78 cells

Zinc deficiency impairs cellular immunity. Up-regulation of mRNA levels of IFN-γ, IL-12Rβ2, and T-bet are essential for Th(1) differentiation. We hypothesized that zinc increases Th(1) differentiation via up-regulation of IFN-γ and T-bet expression. To test this hypothesis, we used zinc-deficient an...

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Bibliographische Detailangaben
Hauptverfasser: Bao, Bin, Prasad, Ananda S., Beck, Frances WJ, Bao, Ginny W., Singh, Tapinder, Ali, Shadan, Sarkar, Fazlul H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142693/
https://ncbi.nlm.nih.gov/pubmed/21439265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.03.084
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