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Calorie restriction extends yeast life span by lowering the level of NADH

Calorie restriction (CR) extends life span in a wide variety of species. Previously, we showed that calorie restriction increases the replicative life span in yeast by activating Sir2, a highly conserved NAD-dependent deacetylase. Here we test whether CR activates Sir2 by increasing the NAD/NADH rat...

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Autori principali: Lin, Su-Ju, Ford, Ethan, Haigis, Marcia, Liszt, Greg, Guarente, Leonard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC314267/
https://ncbi.nlm.nih.gov/pubmed/14724176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1164804
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