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Doxorubicin and daunorubicin induce processing and release of interleukin-1β through activation of the NLRP3 inflammasome

Anthracyclines including doxorubicin and daunorubicin are commonly used for the treatment of both hematologic and solid tumors. Dose related adverse effects often limit the effectiveness of anthracyclines in chemotherapy. Drug-related systemic inflammation mediated by interleukin-1beta (IL-1β) has b...

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Detalhes bibliográficos
Main Authors: Sauter, Kristin AD, Wood, Lisa J, Wong, John, Iordanov, Mihail, Magun, Bruce E
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142364/
https://ncbi.nlm.nih.gov/pubmed/21464611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.12.15540
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