Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck

Both p53 tumor suppressor and murine double minute 2 (MDM2) oncoprotein are crucial in carcinogenesis. We hypothesized that MDM2 promoter single nucleotide polymorphism (SNP)309, A2164G, and p53 codon 72 SNP are associated with risk and age at onset of squamous cell carcinoma of head and neck (SCCHN...

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Main Authors: Yu, Hongping, Huang, Yu-jing, Liu, Zhensheng, Wang, Li-E, Li, Guojun, Sturgis, Erich M., Johson, David G., Wei, Qingyi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142329/
https://ncbi.nlm.nih.gov/pubmed/21656578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20806
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