Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck

Both p53 tumor suppressor and murine double minute 2 (MDM2) oncoprotein are crucial in carcinogenesis. We hypothesized that MDM2 promoter single nucleotide polymorphism (SNP)309, A2164G, and p53 codon 72 SNP are associated with risk and age at onset of squamous cell carcinoma of head and neck (SCCHN...

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Bibliographic Details
Main Authors: Yu, Hongping, Huang, Yu-jing, Liu, Zhensheng, Wang, Li-E, Li, Guojun, Sturgis, Erich M., Johson, David G., Wei, Qingyi
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142329/
https://ncbi.nlm.nih.gov/pubmed/21656578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20806
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