Anti-Islet Autoantibodies Trigger Autoimmune Diabetes in the Presence of an Increased Frequency of Islet-Reactive CD4 T Cells

OBJECTIVE: To define cellular mechanisms by which B cells promote type 1 diabetes. RESEARCH DESIGN AND METHODS: The study measured islet-specific CD4 T cell regulation in T-cell receptor transgenic mice with elevated frequencies of CD4 T cells recognizing hen egg lysozyme (HEL) autoantigen expressed...

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Autori principali: Silva, Diego G., Daley, Stephen R., Hogan, Jennifer, Lee, Sau K., Teh, Charis E., Hu, Daniel Y., Lam, Kong-Peng, Goodnow, Christopher C., Vinuesa, Carola G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2011
Soggetti:
Immunology and Transplantation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142068/
https://ncbi.nlm.nih.gov/pubmed/21788582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1344
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