Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

The multi-subunit DNA-dependent protein kinase (DNA-PK), a crucial player in DNA repair by non-homologous end-joining in higher eukaryotes, consists of a catalytic subunit (DNA-PKcs) and the Ku heterodimer. Ku recruits DNA-PKcs to double-strand breaks, where DNA-PK assembles prior to DNA repair. The...

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Main Authors: Morris, Edward P., Rivera-Calzada, Angel, da Fonseca, Paula C. A., Llorca, Oscar, Pearl, Laurence H., Spagnolo, Laura
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141256/
https://ncbi.nlm.nih.gov/pubmed/21450809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr146
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