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Synthesis of Mercapto (+) methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+) Methamphetamine Conjugate Vaccines

This study reports the synthesis of the mercapto hapten (S)-N-(2-(mercaptoethyl)-6-(3-(2-(methylamino)propyl)phenoxy)hexanamide [3, (+)-METH HSMO9] and its use to prepare METH-conjugated vaccines (MCV) from maleimide activated proteins. MALDI-TOF mass spectrometry analysis of the MCV synthesized usi...

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Hauptverfasser:	Carroll, F. Ivy, Blough, Bruce E., Pidaparthi, Ramakrishna R., Abraham, Philip, Gong, Paul K., Deng, Liu, Huang, Xiaodong, Gunnell, Melinda, Lay, Jackson O., Peterson, Eric C., Owens, S. Michael
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	2011
Schlagworte:	Article
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3141093/ https://ncbi.nlm.nih.gov/pubmed/21682289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2004943
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Synthesis of Mercapto (+) methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+) Methamphetamine Conjugate Vaccines

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