In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

Currently, our knowledge of how pathogenic fungi grow in mammalian host environments is limited. Using a chemotherapeutic murine model of invasive pulmonary aspergillosis (IPA) and (1)H-NMR metabolomics, we detected ethanol in the lungs of mice infected with Aspergillus fumigatus. This result sugges...

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Main Authors: Grahl, Nora, Puttikamonkul, Srisombat, Macdonald, Jeffrey M., Gamcsik, Michael P., Ngo, Lisa Y., Hohl, Tobias M., Cramer, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141044/
https://ncbi.nlm.nih.gov/pubmed/21811407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002145
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