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Characterization of the Channel Constriction Allowing the Access of the Substrate to the Active Site of Yeast Oxidosqualene Cyclase

In oxidosqualene cyclases (OSCs), an enzyme which has been extensively studied as a target for hypocholesterolemic or antifungal drugs, a lipophilic channel connects the surface of the protein with the active site cavity. Active site and channel are separated by a narrow constriction operating as a...

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Autores principales: Oliaro-Bosso, Simonetta, Caron, Giulia, Taramino, Silvia, Ermondi, Giuseppe, Viola, Franca, Balliano, Gianni
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141018/
https://ncbi.nlm.nih.gov/pubmed/21811565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022134
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