Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells

Highly selective therapy for hepatocellular carcinoma (HCC) remains an unmet medical need. In present study, we found that the tumor suppressor microRNA, let-7 was significantly downregulated in a proportion of primary HCC tissues (12 of 33, 36.4%) and HCC cell lines. In line with this finding, we h...

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Bibliografski detalji
Glavni autori: Jin, Huajun, Lv, Saiqun, Yang, Jiahe, Wang, Xiaoning, Hu, Huanzhang, Su, Changqing, Zhou, Chengliang, Li, Jiang, Huang, Yao, Li, Linfang, Liu, Xinyuan, Wu, Mengchao, Qian, Qijun
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140979/
https://ncbi.nlm.nih.gov/pubmed/21814544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021307
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