Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells

Highly selective therapy for hepatocellular carcinoma (HCC) remains an unmet medical need. In present study, we found that the tumor suppressor microRNA, let-7 was significantly downregulated in a proportion of primary HCC tissues (12 of 33, 36.4%) and HCC cell lines. In line with this finding, we h...

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Detalhes bibliográficos
Main Authors: Jin, Huajun, Lv, Saiqun, Yang, Jiahe, Wang, Xiaoning, Hu, Huanzhang, Su, Changqing, Zhou, Chengliang, Li, Jiang, Huang, Yao, Li, Linfang, Liu, Xinyuan, Wu, Mengchao, Qian, Qijun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140979/
https://ncbi.nlm.nih.gov/pubmed/21814544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021307
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