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The Dynamical Mechanism of Auto-Inhibition of AMP-Activated Protein Kinase
We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Na...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140967/ https://ncbi.nlm.nih.gov/pubmed/21814500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002082 |
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