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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
AMPK (AMP-activated protein kinase) is activated allosterically by AMP and by phosphorylation of Thr(172) within the catalytic α subunit. Here we show that mutations in the regulatory γ subunit reduce allosteric activation of the kinase by AMP. In addition to its allosteric effect, AMP significantly...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Portland Press Ltd.
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1828883/ https://ncbi.nlm.nih.gov/pubmed/17147517 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061520 |
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