Plasminogen Activator Inhibitor-Type I Gene Deficient Mice Show Reduced Influx of Neutrophils in Ventilator-Induced Lung Injury

Ventilator-induced lung injury (VILI) is associated with inhibition of the fibrinolytic system secondary to increased production of plasminogen activator inhibitor- (PAI-)1. To determine the role of PAI-1 on pulmonary coagulopathy and inflammation during mechanical ventilation, PAI-1 gene-deficient...

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Main Authors: Wolthuis, Esther K., Vlaar, Alexander P. J., Hofstra, Jorrit-Jan H., Roelofs, Joris J. T. H., de Waard, Vivian, Juffermans, Nicole P., Schultz, Marcus J.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140778/
https://ncbi.nlm.nih.gov/pubmed/21789277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/217896
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