Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice

INTRODUCTION: Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI). Present models of VILI use exceptionally large tidal volumes, causing gross lung injury and haemodynamic shock. In addition, animals are ventilated for a relative short period of time and only after a 'pr...

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Detalhes bibliográficos
Main Authors: Wolthuis, Esther K, Vlaar, Alexander PJ, Choi, Goda, Roelofs, Joris JTH, Juffermans, Nicole P, Schultz, Marcus J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688111/
https://ncbi.nlm.nih.gov/pubmed/19152704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc7688
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