Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver

Niemann-Pick C1-Like 1 (NPC1L1) is highly expressed in the small intestine across mammalian species and is the target of ezetimibe, a potent cholesterol absorption inhibitor. In humans, NPC1L1 is also expressed in the liver. We found that transgenic overexpression of NPC1L1 in the wild-type mouse li...

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Hlavní autoři: Tang, Weiqing, Jia, Lin, Ma, Yinyan, Xie, Ping, Haywood, Jamie, Dawson, Paul A., Li, Jian, Yu, Liqing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140631/
https://ncbi.nlm.nih.gov/pubmed/21683156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2011.05.013
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