Inositol hexakisphosphate kinase 1 (InsP6K1) regulates neutrophil function in innate immunity by inhibiting PtdIns(3,4,5)P3 signaling

Inositol phosphates (InsP) are widely produced throughout animal and plant tissues. Diphosphoinositol pentakisphosphate (InsP7) contains an energetic pyrophosphate bond. Here, we demonstrate that disruption of InsP6K1, one of the three mammalian InsP6Ks that convert InsP6 to InsP7, confers enhanced...

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Main Authors: Prasad, Amit, Jia, Yonghui, Chakraborty, Anutosh, Li, Yitang, Jain, Supriya K., Zhong, Jia, Roy, Saurabh Ghosh, Loison, Fabien, Mondal, Subhanjan, Sakai, Jiro, Blanchard, Catlyn, Snyder, Solomon H., Luo, Hongbo R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140608/
https://ncbi.nlm.nih.gov/pubmed/21685907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2052
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