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Control of regulatory T cell and T(h)17 cell differentiation by inhibitory helix-loop-helix protein Id3
The molecular mechanisms directing Foxp3 gene transcription in CD4(+) T cells remain ill defined. We show that deletion of the inhibitory helix-loop-helix (HLH) protein Id3 results in defective Foxp3(+) T(reg) cell generation. We identified two transforming grothw factor-β1 (TGF-β1)-dependent mechan...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3140164/ https://ncbi.nlm.nih.gov/pubmed/21131965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1965 |
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