PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme and transcription factor that is involved in inflammatory response, but its role in T cell response remains largely unknown. We show here that PARP-1 regulates the suppressive function of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Sp...

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Autores principales: Zhang, Pin, Maruyama, Takashi, Konkel, Joanne E., Abbatiello, Brittany, Zamarron, Brian, Wang, Zhao-qi, Chen, WanJun
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3747222/
https://ncbi.nlm.nih.gov/pubmed/23977081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071590
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