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PARP-1 Controls Immunosuppressive Function of Regulatory T Cells by Destabilizing Foxp3
Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme and transcription factor that is involved in inflammatory response, but its role in T cell response remains largely unknown. We show here that PARP-1 regulates the suppressive function of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Sp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3747222/ https://ncbi.nlm.nih.gov/pubmed/23977081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0071590 |
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