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The development of thymic Foxp3(+) regulatory T cells: TGF-β matters

CD4(+) regulatory T cells expressing the transcription factor Foxp3 can be generated in the thymus (tTreg cells), but the cellular and molecular pathways driving their development remain incompletely understood. Transforming growth factor-beta (TGF-β) is essential for the generation of Foxp3(+) Treg...

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Bibliographic Details
Published in:Eur J Immunol
Main Authors: Chen, WanJun, Konkel, Joanne E.
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4428761/
https://ncbi.nlm.nih.gov/pubmed/25684698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444999
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