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p190RhoGAP links the β1 integrin/caveolin-1 mechano-signaling complex to RhoA and actin remodeling

OBJECTIVE: Hemodynamic shear stress influences endothelial cell phenotype. Integrins and RhoA are essential components in the process that allow endothelial cells to adapt to flow. However, the signaling mechanisms that relay from integrins to RhoA are not well defined. We hypothesized that the β1 i...

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Hlavní autoři: Yang, Baohua, Radel, Chris, Hughes, Dalton, Kelemen, Sheri, Rizzo, Victor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3140163/
https://ncbi.nlm.nih.gov/pubmed/21051664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.110.217794
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