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Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors

Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a family of intracellular Ca(2+) channels that exist as homo- or heterotetramers. In order to determine whether the N-terminal ligand-binding domain is in close physical proximity to the C-terminal pore domain, we prepared microsomal membranes fro...

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Bibliografiske detaljer
Main Authors: Boehning, Darren, Joseph, Suresh K.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC313997/
https://ncbi.nlm.nih.gov/pubmed/11032812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.20.5450
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