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Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Extra-Pulmonary Acute Lung Injury

BACKGROUND: Indirect Acute Lung Injury (ALI) is a common manifestation in critically ill patients. Using a model of indirect ALI in mice, our lab has shown that local/pulmonary inhibition of extrinsic death receptor protein (Fas) leads to a decrease in lung inflammation and improved survival. Howeve...

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Detalhes bibliográficos
Main Authors: Thakkar, Rajan K., Chung, Chun-Shiang, Chen, Yaping, Monaghan, Sean F., Lomas-Neira, Joanne, Heffernan, Daithi S., Cioffi, William G., Ayala, Alfred
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139824/
https://ncbi.nlm.nih.gov/pubmed/21451443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e31821c236d
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