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Hydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary Complex
Results obtained using 2,4-difluorotoluene nucleobase (dF) as a non-polar thymine isostere by Kool and colleagues challenged the Watson-Crick dogma that hydrogen bonds between complementary bases are an absolute requirement for accurate DNA replication. Here we report crystal structure of an RB69 DN...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139434/ https://ncbi.nlm.nih.gov/pubmed/21667997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2021735 |
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