Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis

CREB-binding protein (CREBBP) is important for the cell-autonomous regulation of hematopoiesis, including the stem cell compartment. In the present study, we show that CREBBP plays an equally pivotal role in microenvironment-mediated regulation of hematopoiesis. We found that the BM microenvironment...

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Autors principals: Zimmer, Stephanie N., Zhou, Qing, Zhou, Ting, Cheng, Ziming, Abboud-Werner, Sherry L., Horn, Diane, Lecocke, Mike, White, Ruth, Krivtsov, Andrei V., Armstrong, Scott A., Kung, Andrew L., Livingston, David M., Rebel, Vivienne I.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3139388/
https://ncbi.nlm.nih.gov/pubmed/21555743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307942
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