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Thyrsiferol Inhibits Mitochondrial Respiration and HIF-1 Activation
The cytotoxic marine red algal metabolite thyrsiferol (1) was found to inhibit hypoxia-induced hypoxia-inducible factor-1 (HIF-1) activation in T47D human breast tumor cells (66% inhibition at 3 μM). Compound 1 also suppressed hypoxic induction of HIF-1 target genes (VEGF, GLUT-1) at the mRNA level,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139250/ https://ncbi.nlm.nih.gov/pubmed/21785662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.phytol.2010.09.003 |
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