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Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics
Infection and inflammation are associated with down-regulations of hepatic and extrahepatic cytochrome P450s, as well as other drug metabolizing enzymes and transporters. We will review the genesis of inflammatory reactions, and discuss the relevance of the inflammatory regulation of P450 enzymes ob...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139248/ https://ncbi.nlm.nih.gov/pubmed/19212314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2008.302 |
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