Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

BACKGROUND: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action:...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Geschka, Sandra, Kretschmer, Axel, Sharkovska, Yuliya, Evgenov, Oleg V., Lawrenz, Bettina, Hucke, Andreas, Hocher, Berthold, Stasch, Johannes-Peter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138745/
https://ncbi.nlm.nih.gov/pubmed/21789188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021853
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