Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

BACKGROUND: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action:...

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Bibliografiska uppgifter
Huvudupphovsmän: Geschka, Sandra, Kretschmer, Axel, Sharkovska, Yuliya, Evgenov, Oleg V., Lawrenz, Bettina, Hucke, Andreas, Hocher, Berthold, Stasch, Johannes-Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138745/
https://ncbi.nlm.nih.gov/pubmed/21789188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021853
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