Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt-Sensitive Dahl Rats

BACKGROUND: A direct pharmacological stimulation of soluble guanylate cyclase (sGC) is an emerging therapeutic approach to the management of various cardiovascular disorders associated with endothelial dysfunction. Novel sGC stimulators, including riociguat (BAY 63-2521), have a dual mode of action:...

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Bibliografiske detaljer
Main Authors: Geschka, Sandra, Kretschmer, Axel, Sharkovska, Yuliya, Evgenov, Oleg V., Lawrenz, Bettina, Hucke, Andreas, Hocher, Berthold, Stasch, Johannes-Peter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138745/
https://ncbi.nlm.nih.gov/pubmed/21789188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021853
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