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Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge
The major pharmacophore for the melanocortin 1,3,4 and 5 receptors is the sequence -His-Phe-Arg-Trp-. There is a need for potent, biologically stable, receptor selective ligands, both agonists and antagonists, for these receptors. In this report we briefly examine the structural and biophysical appr...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2011
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3138524/ https://ncbi.nlm.nih.gov/pubmed/21208601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2010.10.109 |
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