Novel Mechanism of Anti-apoptotic Function of 78-kDa Glucose-regulated Protein (GRP78): ENDOCRINE RESISTANCE FACTOR IN BREAST CANCER, THROUGH RELEASE OF B-CELL LYMPHOMA 2 (BCL-2) FROM BCL-2-INTERACTING KILLER (BIK)

Activation of the intrinsic apoptotic pathway represents a major mechanism for breast cancer regression resulting from anti-estrogen therapy. The BH3-only protein BIK is inducible by estrogen-starvation and anti-estrogen treatment and plays an important role in anti-estrogen induced apoptosis of bre...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhou, Hui, Zhang, Yi, Fu, Yong, Chan, Lauren, Lee, Amy S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Cell Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138298/
https://ncbi.nlm.nih.gov/pubmed/21622563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.212944
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