Loss of Cleavage at β′-Site Contributes to Apparent Increase in β-Amyloid Peptide (Aβ) Secretion by β-Secretase (BACE1)-Glycosylphosphatidylinositol (GPI) Processing of Amyloid Precursor Protein

Several lines of evidence implicate lipid raft microdomains in Alzheimer disease-associated β-amyloid peptide (Aβ) production. Notably, targeting β-secretase (β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)) exclusively to lipid rafts by the addition of a glycosylphosphatidylinosito...

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Autori principali: Vetrivel, Kulandaivelu S., Barman, Arghya, Chen, Ying, Nguyen, Phuong D., Wagner, Steven L., Prabhakar, Rajeev, Thinakaran, Gopal
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138254/
https://ncbi.nlm.nih.gov/pubmed/21642424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.260471
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