Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)

Diverse stimuli can feed into the MAPK/ERK cascade; this includes receptor tyrosine kinases, G protein-coupled receptors, integrins, and scavenger receptors (LDL receptor-related protein (LRP)). Here, we investigated the consequence of concomitant occupancy of the receptor tyrosine kinases (by EGF,...

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Detalhes bibliográficos
Main Authors: Geetha, Nishamol, Mihaly, Judit, Stockenhuber, Alexander, Blasi, Francesco, Uhrin, Pavel, Binder, Bernd R., Freissmuth, Michael, Breuss, Johannes M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138245/
https://ncbi.nlm.nih.gov/pubmed/21610072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221903
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