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Total Syntheses and Cytotoxicity of (R)- and (S)-Boehmeriasin A

[Image: see text] Both enantiomers of boehmeriasin A were synthesized in seven steps each using a chiral pool approach. Key steps in the syntheses are a one-flask, two-step protocol to generate the quinolizine core and a C−H functionalization reaction between tetrahydroquinolizinones and an aryltrif...

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Detalhes bibliográficos
Main Authors: Leighty, Matthew W., Georg, Gunda I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138196/
https://ncbi.nlm.nih.gov/pubmed/21779519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1003074
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