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2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance(1)

Gangjee et al. recently reported a novel series of 2-amino-4-methyl-5-phenylethyl substituted-7-benzyl-pyrrolo[2,3-d]pyrimidines, some of which exhibited two digit nanomolar antitumor and antimitotic activity and were not subject to P-glycoprotein (Pgp) or Multidrug Resistance Protein 1 (MRP1) media...

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Detalhes bibliográficos
Main Authors: Gangjee, Aleem, Namjoshi, Ojas A., Keller, Staci N., Smith, Charles D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3138178/
https://ncbi.nlm.nih.gov/pubmed/21680190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.05.030
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