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Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development

Pax6 is a key transcription factor in eye development, particularly in lens development, but its molecular action has not been clarified. We demonstrate that Pax6 initiates lens development by forming a molecular complex with SOX2 on the lens-specific enhancer elements, e.g., the δ-crystallin minima...

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Udgivet i:Genes Dev
Principais autores: Kamachi, Yusuke, Uchikawa, Masanori, Tanouchi, Aki, Sekido, Ryohei, Kondoh, Hisato
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC313803/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11358870/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.887101
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