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Does Anesthetic Additivity Imply a Similar Molecular Mechanism of Anesthetic Action at N-Methyl-d-Aspartate Receptors?
BACKGROUND: Isoflurane and carbon dioxide (CO(2)) negatively modulate N-methyl-D-aspartate (NMDA) receptors, but via different mechanisms. Isoflurane is a competitive antagonist at the NMDA receptor glycine binding site, whereas CO(2) inhibits NMDA receptor current through extracellular acidificatio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137916/ https://ncbi.nlm.nih.gov/pubmed/21233494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e3182080599 |
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