The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, includin...

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Détails bibliographiques
Auteurs principaux: Moreno, Juan A., Izquierdo, Maria C., Sanchez-Niño, Maria D., Suárez-Alvarez, Beatriz, Lopez-Larrea, Carlos, Jakubowski, Aniela, Blanco, Julia, Ramirez, Rafael, Selgas, Rafael, Ruiz-Ortega, Marta, Egido, Jesus, Ortiz, Alberto, Sanz, Ana B.
Format: Artigo
Langue:Inglês
Publié: American Society of Nephrology 2011
Sujets:
Basic Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137579/
https://ncbi.nlm.nih.gov/pubmed/21719790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010101073
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