The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, includin...

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Bibliografiske detaljer
Main Authors: Moreno, Juan A., Izquierdo, Maria C., Sanchez-Niño, Maria D., Suárez-Alvarez, Beatriz, Lopez-Larrea, Carlos, Jakubowski, Aniela, Blanco, Julia, Ramirez, Rafael, Selgas, Rafael, Ruiz-Ortega, Marta, Egido, Jesus, Ortiz, Alberto, Sanz, Ana B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2011
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137579/
https://ncbi.nlm.nih.gov/pubmed/21719790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010101073
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