The Inflammatory Cytokines TWEAK and TNFα Reduce Renal Klotho Expression through NFκB

Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cells that has antiaging properties; Klotho-deficient mice have an accelerated aging-like phenotype, includin...

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Detalhes bibliográficos
Main Authors: Moreno, Juan A., Izquierdo, Maria C., Sanchez-Niño, Maria D., Suárez-Alvarez, Beatriz, Lopez-Larrea, Carlos, Jakubowski, Aniela, Blanco, Julia, Ramirez, Rafael, Selgas, Rafael, Ruiz-Ortega, Marta, Egido, Jesus, Ortiz, Alberto, Sanz, Ana B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2011
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137579/
https://ncbi.nlm.nih.gov/pubmed/21719790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010101073
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