Genomic inflation factors under polygenic inheritance

Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single-nucleotide-polymorphisms across the genome i...

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Autors principals: Yang, Jian, Weedon, Michael N, Purcell, Shaun, Lettre, Guillaume, Estrada, Karol, Willer, Cristen J, Smith, Albert V, Ingelsson, Erik, O'Connell, Jeffrey R, Mangino, Massimo, Mägi, Reedik, Madden, Pamela A, Heath, Andrew C, Nyholt, Dale R, Martin, Nicholas G, Montgomery, Grant W, Frayling, Timothy M, Hirschhorn, Joel N, McCarthy, Mark I, Goddard, Michael E, Visscher, Peter M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137506/
https://ncbi.nlm.nih.gov/pubmed/21407268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.39
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