Genomic inflation factors under polygenic inheritance

Population structure, including population stratification and cryptic relatedness, can cause spurious associations in genome-wide association studies (GWAS). Usually, the scaled median or mean test statistic for association calculated from multiple single-nucleotide-polymorphisms across the genome i...

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Detalhes bibliográficos
Main Authors: Yang, Jian, Weedon, Michael N, Purcell, Shaun, Lettre, Guillaume, Estrada, Karol, Willer, Cristen J, Smith, Albert V, Ingelsson, Erik, O'Connell, Jeffrey R, Mangino, Massimo, Mägi, Reedik, Madden, Pamela A, Heath, Andrew C, Nyholt, Dale R, Martin, Nicholas G, Montgomery, Grant W, Frayling, Timothy M, Hirschhorn, Joel N, McCarthy, Mark I, Goddard, Michael E, Visscher, Peter M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137506/
https://ncbi.nlm.nih.gov/pubmed/21407268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2011.39
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