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Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase
Phosphonoformic acid (PFA, foscarnet) belongs to a class of antiviral drugs that inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction. Difficulties expressing UL54 have hampered investigation of the precise structura...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3137095/ https://ncbi.nlm.nih.gov/pubmed/21566148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248864 |
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