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Phosphonoformic Acid Inhibits Viral Replication by Trapping the Closed Form of the DNA Polymerase

Phosphonoformic acid (PFA, foscarnet) belongs to a class of antiviral drugs that inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction. Difficulties expressing UL54 have hampered investigation of the precise structura...

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Bibliografiske detaljer
Main Authors: Zahn, Karl E., Tchesnokov, Egor P., Götte, Matthias, Doublié, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137095/
https://ncbi.nlm.nih.gov/pubmed/21566148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248864
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