The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor

Baloxavir marboxil (BXM) is an FDA-approved antiviral prodrug for the treatment of influenza A and B infection and postexposure prophylaxis. The active form, baloxavir acid (BXA), targets the cap-snatching endonuclease (PA) of the influenza virus polymerase complex. The nuclease activity delivers th...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Todd, Brendan, Tchesnokov, Egor P., Götte, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8065212/
https://ncbi.nlm.nih.gov/pubmed/33647314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100486
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